Free Radicals

Free radicals, more accurately described as atoms or molecules with unpaired electrons, are highly reactive and readily undergo chemical reactions. Free radicals and their precursors can be produced endogenously through normal metabolic processes or exogenously through air pollutants, smoking and other sources. The body's natural defense mechanism to neutralize free radicals is the production and regeneration of antioxidants. When the concentration of free radicals exceeds the neutralizing capability of the body's antioxidants, these highly reactive species can damage vital molecules such as DNA, RNA, enzymes and structural proteins and large amounts of membrane lipids though peroxidation.

Vitamins and minerals are the most common forms of antioxidants within the body. Beta-Carotene, a member of the carotenoid family, supports normal functioning of the immune system and promotes ocular health. It promotes the normal development and differentiation of white blood cells that play a critical role in our immune system. Beta-Carotene is also metabolized into retinoic acid, a hormone that promotes normal embryonic development and the transcription of the gene for growth hormone. Vitamin C is a highly effective antioxidant, even in small amounts. It has been shown to protect critical molecules in the body such as lipids, proteins, and nucleic acids from free radicals and reactive oxygen species. Vitamin E is a fat-soluble antioxidant that protects vulnerable fatty acids in cell membranes from lipid peroxidation. It has also been shown to reduce the lipid oxidation of low-density lipoprotein (LDL) particles, thus promoting cardiovascular health. Other antioxidants such as vitamin C are involved in regenerating the antioxidant capability of vitamin E. Minerals are also key components of our immune system. Our body uses selenium-dependent enzymes known as selenoproteins to neutralize reactive oxygen species as well as reactive nitrogen species. Glutathione peroxidases are a group of selenoprotein enzymes that reduce reactive oxygen species such as hydrogen peroxide and lipid hydroperoxides to harmless products such as water and simple alcohols. Thioredoxin reductase is another selenium-dependent enzyme that participates in the regeneration of antioxidant systems, including vitamin C. Maintaining thioredoxin in its reduced form by thioredoxin reductase is important in supporting normal cell growth and vitality. Selenium deficiency has been strongly correlated with a weakened immune system.

Aside from the established health benefits of vitamins and minerals found in food, ancient medicine has introduced us to the world of herbal antioxidants. Green tea, a health-promoting antioxidant, is full of a powerful class of flavonoids known as catechins. Bilberry, a source of anthocyanidins has demonstrated health benefits ranging from cardiovascular health maintenance to support of cognitive brain function and vision. The powerful herb milk thistle has been widely used for almost 2000 years to support liver health. Medical doctor Kara Kelly and research scientist Janice Post-White state that preclinical evidence, both in vivo and in vitro, suggests that milk thistle promotes cellular health. It is effective in promoting cell health by promoting normal levels of nuclear factor-kappa B (NF-êB). NF-êB is a transcription factor that activates cytokines, chemokines and leukocyte adhesion molecules involved in inflammatory responses. In an effort to reduce free radicals and promote optimal health, these vitamins, minerals and herbal antioxidants provide a safe, yet powerful supplement to our diet.*

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

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